| Select Package | Enter Quantity | Per Pill Price | Price |
|---|---|---|---|
| $3 | $180 | ||
| $2.9 | $435 | ||
| $2.8 | $700 | ||
| $2.7 | $945 | ||
| $2.6 | $1300 |
Modafinil is an FDA-approved wakefulness-promoting agent (eugeroic) prescribed to treat excessive daytime sleepiness caused by sleep disorders. Sold under the brand name Provigil, it works by modulating key neurotransmitters in the brain — including dopamine, norepinephrine, and histamine — to promote sustained wakefulness without the harsh side effects of traditional stimulants.
Generic modafinil is chemically identical to Provigil and approved to the same FDA bioequivalence standards. It offers the same therapeutic effect at a fraction of the brand-name cost.
Armodafinil is the next-generation eugeroic — the purified R-enantiomer of modafinil. It works at a lower dose (150mg vs 200mg), lasts up to 15 hours, and provides more consistent wakefulness throughout the day.
→ View Armodafinil HereModafinil is FDA-approved for three sleep disorder conditions and widely used off-label for cognitive performance.
Reduces the frequency and severity of sudden sleep attacks and excessive daytime sleepiness in narcolepsy patients. Standard dose: 200mg in the morning.
Used as adjunct therapy alongside CPAP. Reduces residual daytime fatigue in OSA patients where CPAP alone is not fully effective. Dose: 200mg each morning.
Helps nurses, security staff, pilots, and factory workers maintain alertness during night shifts or rotating work schedules. Taken 1 hour before shift.
Standard clinical dosages by condition. Always follow your prescriber's instructions.
| Condition | Standard Dose | When to Take | Max Daily Dose |
|---|---|---|---|
| Narcolepsy | 200mg | Once in the morning | 400mg (split AM/noon) |
| Obstructive Sleep Apnea | 200mg | Once in the morning | 400mg |
| Shift Work Sleep Disorder | 200mg | 1 hour before shift starts | 200mg |
| Off-label (Cognitive) | 100–200mg | Morning (or before task) | 200mg recommended |
| Dose | Best For | Duration | Side Effect Risk |
|---|---|---|---|
| 100mg | First-time users, sensitive individuals, microdosing | 8–10 hours | Lower |
| 200mg | Standard prescribed dose for most conditions | 10–12 hours | Moderate |
| 400mg | Severe narcolepsy, split into two doses | 12–15 hours | Higher |
Modafinil is a moderate inducer of CYP3A4 and inhibitor of CYP2C19. This affects the metabolism of many commonly used medications.
| Drug / Drug Class | Interaction | Risk Level |
|---|---|---|
| Hormonal contraceptives (pill, patch, implant, ring) | Significantly reduced effectiveness — risk of unintended pregnancy | HIGH |
| Cyclosporine (immunosuppressant) | Reduced blood plasma levels of cyclosporine | HIGH |
| Warfarin (blood thinner) | Increased warfarin levels — INR must be monitored closely | HIGH |
| MAOIs (e.g., phenelzine, selegiline) | Risk of serious cardiovascular and CNS interactions | HIGH |
| Alcohol | Modafinil may mask intoxication; worsens dehydration and side effects | AVOID |
| Caffeine | Increased risk of anxiety, palpitations, elevated heart rate | MODERATE |
| Diazepam / phenytoin (CYP2C19 substrates) | Modafinil inhibits CYP2C19 — may raise plasma levels of these drugs | MODERATE |
| Clomipramine / tricyclic antidepressants | Elevated TCA levels possible — monitor for toxicity | MODERATE |
Both are eugeroics from the same drug family. Here is a detailed head-to-head comparison to help you choose.
| Feature | Modafinil | Armodafinil |
|---|---|---|
| Chemical type | Racemic mixture (R + S enantiomers) | R-enantiomer only (single isomer) |
| Standard dose | 200mg | 150mg (lower dose needed) |
| Half-life | ~12 hours | ~15 hours (longer acting) |
| Wakefulness pattern | Strong initial peak, tapers off | More consistent, sustained plateau |
| Duration of effect | 10–12 hours | 12–15 hours |
| Side effect profile | Slightly milder at standard dose | Slightly more potent |
| Best for | First-time users, shorter tasks, value | Narcolepsy, night shifts, all-day focus |
| DEA Schedule | Schedule IV | Schedule IV |
| Price at MyOnlineMedshop | From $2.50/pill | From $3.00/pill |
Provigil is the original brand-name modafinil manufactured by Cephalon (now Teva Pharmaceuticals). When its patent expired, FDA-approved generic manufacturers began producing the identical molecule. Generic modafinil is bioequivalent to Provigil — meaning it is absorbed, distributed, and metabolised identically by the body. The only difference is cost.
| Source | Price per Pill | Prescription Required? | Notes |
|---|---|---|---|
| US Pharmacy (Provigil brand) | $20–25 | Required | Brand name, highest cost |
| US Pharmacy (generic w/ GoodRx coupon) | ~$1–3 | Required | Requires valid US prescription |
| MyOnlineMedShop BEST | From $2.50/pill | Not Required | Generic, worldwide shipping, discreet |
For off-label cognitive use, taking modafinil daily can gradually reduce its effectiveness over several weeks. A cycling strategy helps maintain full potency. For clinically prescribed use (narcolepsy, OSA, shift work disorder), follow your prescriber's dosing schedule.
ON = Take modafinil -- = Rest day (no dose). Weekend rest days allow dopamine receptor sensitivity to normalise, keeping modafinil fully effective on working days.
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Narcolepsy / OSA: 200mg taken once daily in the morning. May be taken with or without food.
Shift Work Disorder: 200mg taken approximately 1 hour before the start of the work shift.
First-time users: Consider starting with 100mg to assess individual tolerance and sensitivity.
Do not take after noon to avoid interfering with night-time sleep. Do not crush or split the tablet. If a dose is missed, skip it — do not take a double dose.
Generic Name: Modafinil
Brand Name: Provigil (Teva Pharmaceuticals)
Drug Class: Wakefulness-Promoting Agent (Eugeroic)
DEA Schedule: Schedule IV Controlled Substance
Mechanism: Modafinil promotes wakefulness by inhibiting dopamine reuptake and modulating norepinephrine, histamine, orexin, and serotonin neurotransmitter systems in the hypothalamus and prefrontal cortex.
Available Forms: Oral tablets — 100mg, 200mg
Common Generic Brands: Modalert (Sun Pharma), Modvigil (HAB Pharma)
Is generic modafinil the same as Provigil?
Yes. Generic modafinil contains the identical active ingredient at the same dose and bioavailability as brand-name Provigil — FDA-approved to be therapeutically equivalent. The only difference is price.
What is Modafinil used for?
FDA-approved for narcolepsy, obstructive sleep apnea (as CPAP adjunct), and shift work sleep disorder. Widely used off-label for cognitive enhancement, focus, and fatigue reduction.
How long does Modafinil take to work?
Effects begin in 30–60 minutes, peak at 2–4 hours, and last 10–12 hours. Effects may be slightly delayed when taken with a high-fat meal.
What are the most common side effects?
Headache (~34%), nausea (~11%), anxiety, dry mouth, insomnia (if taken late), decreased appetite. Most are mild and dose-dependent.
Is Modafinil addictive?
Classified Schedule IV — low abuse potential compared to traditional stimulants. Physical dependence is rare with therapeutic use. Psychological reliance is possible with daily off-label use.
Does Modafinil affect birth control?
Yes — it reduces the effectiveness of hormonal contraceptives (pills, patches, implants) significantly. Use non-hormonal backup contraception during treatment and for one month after stopping.
How long does Modafinil stay in your system?
Half-life of 12–15 hours. Detectable in urine for 2–4 days depending on metabolism and test sensitivity.
Can I take Modafinil every day?
For prescribed conditions, daily use is standard. For off-label cognitive use, cycling (5 days on, 2 off) is recommended to prevent tolerance buildup.
Modafinil vs Armodafinil — which is stronger?
Armodafinil is more potent per milligram and lasts longer (15 hrs vs 12 hrs). However, modafinil's dual-isomer profile means a faster initial onset. Neither is strictly "stronger" — they suit different use cases.
Can Modafinil be used for jet lag?
Used off-label by pilots, military personnel, and frequent travellers to manage circadian disruption and maintain cognitive function across time zones. Not FDA-approved for this purpose.
Can I drink alcohol with Modafinil?
Not recommended. Modafinil may mask the perceived effects of alcohol, leading to overconsumption. It also increases dehydration and worsens headaches.
Is Modafinil safe during pregnancy?
Avoid. Animal studies suggest potential fetal harm. Women of childbearing age must use reliable non-hormonal contraception during treatment. Notify a prescriber immediately if pregnancy occurs.
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All product information is reviewed against FDA prescribing data, NIH MedlinePlus, and Drugs.com by a qualified pharmacotherapy specialist.
We supply only from licensed, quality-certified manufacturers (e.g., Sun Pharma, HAB Pharma). Generic modafinil — same molecule, same bioavailability as Provigil.
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