Zopiclone

Recommended dose: 3.75–7.5 mg taken orally immediately before bedtime. Elderly patients should start with 3.75 mg to reduce the risk of over-sedation and falls.

• Take Zopiclone only when you are ready to sleep immediately and have at least 7–8 hours available before waking.
• Swallow the tablet whole — do not crush or chew.
• Can be taken with or without food. Avoid taking after a heavy meal as it may delay onset.
• Do not take a second dose the same night.
• Zopiclone is recommended for short-term use only (typically 2–4 weeks). Do not use longer than prescribed without consulting your doctor.
• Do not stop Zopiclone suddenly after extended use — taper gradually under medical supervision to avoid withdrawal symptoms including rebound insomnia and anxiety.

Generic: Zopiclone
Brand: Imovane / Zimovane / Dopareel
Category: Sedative-Hypnotic / Non-Benzodiazepine Sleep Aid (Z-Drug)
Available Forms: Oral tablets
Available Strengths: 3.75 mg, 7.5 mg

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What is Zopiclone used for?
Zopiclone is used for the short-term treatment of insomnia — including difficulty falling asleep, frequent nighttime awakenings, and early morning waking. It is intended for use over 2–4 weeks only.

How long does Zopiclone take to work?
Zopiclone typically begins working within 30–60 minutes of taking the dose. Effects last approximately 6–8 hours, making it well-suited for a full night of sleep.

What are common side effects?
A bitter or metallic taste in the mouth (very common), drowsiness, dizziness, dry mouth, headache, and next-morning grogginess. The bitter aftertaste is the most frequently reported side effect with Zopiclone.

Is Zopiclone addictive?
Yes. Zopiclone can cause physical and psychological dependence, especially with long-term use or doses higher than prescribed. It is intended for short-term use only and should always be used under medical supervision.

Zopiclone vs Zolpidem (Ambien) — what is the difference?
Both are non-benzodiazepine Z-drugs for insomnia. Zolpidem (Ambien) acts faster (15–30 min) and is more widely used in the USA. Zopiclone has a slightly longer duration and is more commonly prescribed outside the USA. Both carry similar risks of dependence and complex sleep behaviors.

Can Zopiclone cause serious side effects?
Rare but serious: complex sleep behaviors (sleepwalking, sleep-driving), severe allergic reactions, severe memory impairment, respiratory depression (especially with alcohol or opioids), and paradoxical reactions such as increased agitation or aggression. Discontinue immediately if complex sleep behaviors occur.

Is Zopiclone safe in pregnancy?
No. Zopiclone is not recommended during pregnancy. It may cause neonatal withdrawal symptoms and respiratory depression in newborns. Avoid during pregnancy and breastfeeding — consult your doctor for safer alternatives.

How long does Zopiclone stay in your system?
Half-life is approximately 3.5–6.5 hours. Zopiclone is generally detectable in urine for 24–48 hours after the last dose.

Can I take Zopiclone with food?
Yes. Zopiclone can be taken with or without food. However, avoid taking it after a large, high-fat meal as this may delay its sleep-inducing effect.

Can I drink alcohol with Zopiclone?
No. Combining Zopiclone with alcohol significantly increases CNS depression, causes extreme sedation, and greatly increases the risk of dangerous complex sleep behaviors and respiratory depression. Strictly avoid alcohol during use.