Pfizer first marketed Celecoxib as an arthritic treatment. John Talley of Monsanto's Searle subsidiary led a team that found Celecoxib and additional COX-2 selective inhibitors such as valdecoxib, parecoxib, and mavacoxib. Celecoxib's discovery resulted in two lawsuits. In 1988, Brigham Young University's Daniel L. Simmons discovered the COX-2 enzyme, and in 1991, BYU and Monsanto formed a partnership to explore medications to block it. Pfizer eventually purchased Monsanto's pharmaceutical division, and BYU sued Pfizer for breach of contract in 2006, alleging that Pfizer failed to pay contractual payments to BYU. In April 2012, Pfizer agreed to pay $450 million as a settlement. Rochester University made other significant COX-2 findings.
Celecoxib is used to treat osteoarthritis, the type of arthritis caused by a breakdown of the joint lining, rheumatoid arthritis (arthritis caused by swelling of the joint lining), and ankylosing spondylitis, which causes pain, soreness, swelling, and stiffness (arthritis that mainly affects the spine). Celecoxib is also used to treat children aged two and up with juvenile rheumatoid arthritis (a kind of arthritis that affects children). Celecoxib is also used to manage painful menstrual cycles and other types of short-term pain, such as pain caused by injuries, surgery, other medical or dental operations, or pain caused by short-term medical disorders. Celecoxib belongs to the COX-2 inhibitors class of NSAIDs. Abdominal pain, nausea, and diarrhea are all common adverse effects. Heart attacks, strokes, gastrointestinal perforation, bleeding, kidney failure, and anaphylaxis are serious side effects. People at a high risk of heart disease should avoid using it. Other NSAIDs, such as ibuprofen and naproxen, have similar concerns. It is not advised to use during the last trimester of pregnancy or while breastfeeding. Celecoxib was first approved for medicinal use in 1999 after being patented in 1993. It's a drug that's available as a generic. With over 6 million prescriptions written in 2019, it was the 102nd most widely prescribed drug in the United States. People with a history of ulcer disease or GI bleeding should take extra care. In persons using NSAIDs, moderate to severe liver damage or GI toxicity can occur with or without warning symptoms.
The US FDA has legalized that all nonsteroidal anti-inflammatory drugs' drug labels be amended by October 2020 to include information about the risk of kidney issues in unborn newborns due to low amniotic fluid. They advise pregnant women who are 20 weeks or later in their pregnancy to avoid NSAIDs. Therefore, Celecoxib has various uses in the medical industry, doctors recommend this medicine to their patients, but you have to be specific with its dosage. Before buying the medicine, please consult your health expert; they will provide you exact quantity and timing of the Celecoxib. Once your health expert approves Celecoxib, you should buy it from an authentic website like myonlinemedshop.com, where you can buy Celecoxib online at the best price, with original packing. Moreover, you can get various medicines and their descriptions at our official website where you can choose a suitable medicine according to your requirement and order them with just a few clicks.
Heart Effects: Celecoxib has been linked to an increased risk of serious (and potentially fatal) adverse cardiovascular thrombotic events, such as myocardial infarction and stroke. Longevity of use, as well as pre-existing cardiovascular risk factors or disease, may raise the risk. Before medication, individual cardiovascular risk profiles should be assessed. New-onset hypertension or hypertension aggravation (NSAIDs may impede responsiveness to thiazide or loop diuretics), as well as cardiovascular events, may occur; monitor blood pressure and use with caution in individuals with hypertension. Use caution in patients with edema or heart failure since it can promote salt and fluid retention. Children's long-term cardiovascular risk has not been studied. To limit the risk of cardiovascular events, use the lowest effective dose for the shortest term, commensurate with individual patient goals; alternative therapy should be sought for individuals at high risk.
Affect Your Intestines: The risk has increased by around 37%. Celecoxib has been linked to an increased risk of major GI ulcers, bleeding, and perforation (may be fatal). These incidents might happen at any time and without warning throughout therapy; with a history of GI disease, concurrent aspirin, anticoagulants, corticosteroids medication, smoking, alcohol usage, the elderly, or debilitated patients, exercise caution. To limit the risk of GI adverse effects, use the lowest effective dose for the shortest term, commensurate with individual patient goals; alternative therapy should be sought for patients at high risk. When used with 325 mg of aspirin, the risk of gastrointestinal problems (e.g., ulcer) increases significantly; concurrent gastroprotective medication (e.g., proton pump inhibitors) is suggested. If you're on long-term treatment, keep an eye on your hemoglobin or hematocrit levels.
Treat Allergies: At recommended doses, Celecoxib does not affect prothrombin time, partial thromboplastin time, or platelet counts, and it does not suppress platelet aggregation. Celecoxib has a sulfonamide component, which might induce allergic responses in people allergic to sulfonamides. This is in addition to the fact that it is not recommended for persons who have severe NSAID sensitivities. It does, however, have a minimal (reportedly 4%) risk of causing cutaneous reactions in people who have previously had such reactions to aspirin or nonselective NSAIDs. Celecoxib is used to treat osteoarthritis, acute pain, musculoskeletal discomfort, painful menstruation, ankylosing spondylitis, juvenile rheumatoid arthritis, and reduce the number of polyps in the colon and rectal tract persons with familial adenomatous polyposis. It can be used in children over two who have juvenile rheumatoid arthritis and weigh more than 10 kg (22 lb). It's comparable to ibuprofen in terms of postoperative pain.
Used To Treat Various Types Of Arthritis: It's equivalent to paracetamol (acetaminophen) for pain reduction, the first-line treatment for osteoarthritis. It's been used to shrink colon and rectal polyps in persons with familial adenomatous polyposis, but it's unclear whether it lowers cancer rates. Therefore, Celecoxib has various uses, and doctors recommend it to every patient suffering from any allergy or heart disease.
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Cancer treatment, in contrast to cancer prevention, focuses on treating cancers that have already grown and established themselves within the patient. Many studies are currently being conducted to see if Celecoxib can help with this condition. However, it was discovered during laboratory molecular research that Celecoxib could interact with intracellular components other than its most well-known target, COX-2. The discovery of these other targets has sparked debate, and the initial hypothesis that Celecoxib inhibits tumor growth solely by inhibiting COX-2 has become debatable. Various researchers have looked into the effect of Celecoxib in lowering the incidence of different malignancies. However, there is no medical prescription for using this medicine to reduce cancer risk. Celecoxib has been studied for its ability to reduce the risk of colorectal cancer, but neither it nor any other medicine is approved for this purpose. Celecoxib has been shown to inhibit polyp formation in small-scale clinical trials in very high-risk persons (those from FAP families). As a result, large-scale randomized clinical studies were carried out.
People who took Celecoxib every day saw a 33 to 45 percent reduction in polyp recurrence. On the other hand, serious cardiovascular events were considerably more common in the celecoxib-treated groups. Although aspirin has a similar (and possibly more significant) protective impact, has been shown to have cardioprotective properties, and is substantially less expensive, no head-to-head clinical trials have been conducted to compare the two medicines. Celecoxib's anti-inflammatory and analgesic properties are unquestionably dependent on COX-2 inhibition. However, it's uncertain whether COX-2 inhibition plays a significant part in this drug's anticancer benefits. For example, Celecoxib could reduce cell growth in vitro, but COX-2 had no impact on this outcome; even more startling, Celecoxib's anticancer effects were obtained using cancer cell types that did not include COX-2.
According to Karen Seibert and colleagues, Celecoxib has been shown to have antiangiogenic and anticancer properties. Studies utilizing chemically modified forms of Celecoxib have added to the evidence that other targets besides COX-2 are key for Celecoxib's anticancer effects. Several dozen celecoxib analogs were created by making minor changes to their chemical structures. COX-2 inhibitory action was conserved in some of these analogs but not others. When all of these drugs were tested for their capacity to kill tumor cells in cell culture, the antitumor potency did not depend on whether or not they could inhibit COX-2, indicating that COX-2 inhibition was not required for anticancer effects. One of these molecules, 2,5-dimethyl-celecoxib, which cannot inhibit COX-2, actually outperformed Celecoxib in terms of anticancer efficacy. Therefore, you can consume Celecoxib to prevent or cure cancer, but you need a health expert's supervision to determine your dosage. Hence, if you want to buy Celecoxib from a trustful website, visit myonlinemedshop.com, where we offer various medicines at cheap rates and fast delivery.
Prefer Using After Heart Surgery: Celecoxib is contraindicated for treating perioperative pain in the setting of coronary artery bypass graft surgery due to its cardiovascular risk. Celecoxib has a sulfonamide group and is, therefore, contraindicated in patients who have had severe allergic responses to sulfonamide-containing medications, such as sulfamethoxazole. Allergies to sulfonamide antimicrobials are a risk factor for allergic reactions to the sulfonamide chemical group in studies. A history of penicillin allergy is a significant risk factor for an allergic reaction as non-antimicrobial medications that include a sulfonamide chemical group, such as Celecoxib. As a result, this phenomenon is unlikely to be caused exclusively by cross-reactivity between sulfonamide-containing antimicrobials and non-antimicrobials. Certain patients who are allergic to any antimicrobial medicine are more prone to develop celecoxib allergy. Because CYP2C9 metabolizes Celecoxib, it should be used cautiously in patients taking CYP2C9 inhibitors, such as fluconazole, an antifungal agent. Celecoxib, like all NSAIDs, should not be used after 29 weeks of pregnancy. Unfortunately, there are no antidotes for celecoxib overdose.
Avoid Overdosing: On the other hand, Celecoxib is a relatively safe medicine in general. There were no reports of celecoxib overdoses during FDA testing, and doses up to 2400 mg per day for ten days did not cause severe toxicity. If you are allergic to Celecoxib, aspirin, or other NSAIDs (such as ibuprofen, naproxen), or if you have any other allergies, notify your health expert or pharmacist before taking it. Inactive chemicals may be included in this product, causing allergic reactions or other issues. Tell your health expert or pharmacist about any medical conditions, especially if you have asthma or nasal growths (nasal polyps). NSAID drugs, such as Celecoxib, might cause kidney issues in certain people. If you're dehydrated or are an older adult, you're more likely to have problems. To avoid dehydration, drink plenty of fluids as advised by your doctor, and report any odd changes in the amount of urine to your doctor right away.
Avoid Smoking: This medication has the potential to induce stomach bleeding. Consumption of alcohol and tobacco regularly, particularly when coupled with this drug, may raise your risk of stomach bleeding. Limit your alcohol intake and quit smoking. While taking this medication, older persons may be more susceptible to stomach/intestinal bleeding, kidney issues, heart attack, and stroke. Women of childbearing age should discuss the advantages and dangers of this drug with their doctor(s) before taking it. If you are pregnant, tell your health expert. This medicine can damage an unborn child and cause complications during normal labor and delivery.
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Prescribers must monitor patients for adverse drug reactions such as new or worsening hypertension, renal toxicity, liver toxicity, anaphylactic reactions, and skin changes ranging from a non-severe rash to more severe reactions such as Stevens-Johnson syndrome. Prescribers should keep an eye on a patient's blood pressure, kidney, and liver function, as well as signs and symptoms of gastrointestinal bleeding. Visit myonlinemedshop.com to buy Celecoxib at the best price, and read our expert's explanation to learn more about the drug. Your order will be placed and delivered to your doorsteps in a few days after you complete the payment.